- Lille vs Wolfsburg = pukul 02:00 WIB
- Villareal vs Atalanta = pukul 02:00 WIB
- Barcelona vs Bayern Munchen = pukul 02:00 WIB
- Dynamo Kyiv vs Benfica = pukul 02:00 WIB
- Sheriff vs Shakhtar Donetsk = pukul 02:00 WIB
- Besiktas vs Dortmund = pukul 23:45 WIB
16 September 2021
- Inter Milan vs Real Madrid = pukul 02:00 WIB
- Sporting vs Ajax = pukul 02:00 WIB
- Atletico Madrid vs Porto = pukul 02:00 WIB