- Barcelona vs Benfica = 24 November 2021 pukul 03:00 WIB
- Sevilla vs Wolfsburg = 24 November 2021 pukul 03:00 WIB
- Malmo vs Zenit = 24 November 2021 pukul 03:00 WIB
- Lille vs Salzburg = 24 November 2021 pukul 03:00 WIB
- Young Boys Atalanta = 24 November 2021 pukul 03:00 WIB
25 November 2021
- Besiktas vs Ajax= 25 November 2021 pukul 00:45 WIB
- Inter Milan vs Shakhtar Donetsk= 25 November 2021 pukul 00:45 WIB
- Sporting vs Dortmund = 25 November 2021 pukul 03:00 WIB