- Club Brugge vs PSG = pukul 02:00 WIB
- Manchester City vs Leipzig = pukul 02:00 WIB
matchday 2
28 September 2021
- Ajax vs Besiktas = 28 September 2021 pukul 23:45 WIB
- Shakhtar Donetsk vs Inter Milan = 28 September 2021 pukul 23:45 WIB
29 September 2021
- Atalanta vs Young Boys = 29 September 2021 pukul 23:45 WIB
- PSG vs Manchester City = 29 September 2021 pukul 02:00 WIB
- Leipzig vs Club Brugge = 29 September 2021 pukul 02:00 WIB