- Juventus vs Zenit = 3 November 2021 pukul 03:00 WIB
- Bayern Munchen vs Benfica = 3 November 2021 pukul 03:00 WIB
- Sevilla vs Lille = 3 November 2021 pukul 03:00 WIB
- Dynamo Kyiv vs Barcelona = 3 November 2021 pukul 03:00 WIB
- Atalanta vs Manchester United = 3 November 2021 pukul 03:00 WIB
4 November 2021
- Real Madrid vs Shakhtar Donetsk = 4 November 2021 pukul 00:45 WIB
- AC Milan vs Porto = 4 November 2021 pukul 00:45 WIB
- Sporting vs Besiktas = 4 November 2021 pukul 03:00 WIB
- Dortmund vs Ajax = 4 November 2021 pukul 03:00 WIB