- Atalanta vs Young Boys = 29 September 2021 pukul 23:45 WIB
- PSG vs Manchester City = 29 September 2021 pukul 02:00 WIB
- Leipzig vs Club Brugge = 29 September 2021 pukul 02:00 WIB
- AC Milan vs Atletico Madrid = 29 September 2021 pukul 02:00 WIB
- Porto vs Liverpool = 29 September 2021 pukul 02:00 WIB
- Dortmund vs Sporting = 29 September 2021 pukul 02:00 WIB
- Real Madrid vs Sheriff = 29 September 2021 pukul 02:00 WIB
- Zenit vs Malmo = 29 September pukul 02:00 WIB
30 September 2021
- Wolfsburg vs Sevilla = 30 September 2021 pukul 23:45 WIB